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Paediatr Indones

For active adults, this can be frustrating

Withdrawal from opioids can make a person feel sleepy, but they may also have difficulty getting good quality sleep

This paradox arises from the inherent complexity of MS pathogenesis which we argue is driven by a convolution of relapsing/acute adaptive autoimmunity and chronic cytodegeneration (cyto-is used here rather than neuro-to underscore the point that myelin/oligodendrocytes are the likely primary targets of this process), including an elaborate innate immune response (Figure 1)