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Even more frequently, non-specific resistance mechanisms, involving modification of cell envelope charge, composition or rigidity as well as increased expression of drug resistance transporters can contribute to resistance

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The conversion from homocysteine to cystathionine by cystathionine -synthase (CBS) is described to be a key player in restoring intracellular cysteine pool as decreasing its expression increases sensitivity to ferroptosis in ovarian cancer cells upon erastin treatment (54)

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