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Discussion In this trial of patients with type 2 diabetes and CKD who were randomized to receive canagliflozin or placebo, we showed that baseline IGF-1 levels and IGF-1/IGFBP-3 ratio (but not IGFBP-3 concentrations) were associated with cardio-renal outcomes

Synthetic arginase inhibitors (e.g., Nor-NOHA) also show the potential to modulate ARG1 expression and MDSC function to improve immunotherapy outcomes (46)

The novel uricosurics agent including lesinurad, arhalofenate, canagliflozin, xanthine oxidase inhibitor tetrapeptide EEAK, rhodiola crenulata, favipiravir, PF-06743649 increase renal urate excretion by inhibiting reabsorption