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In addition, antagonists of corticotropin-releasing factor 1 (CRF 1) have some antidepressant and anti-anxiety effects [69, 70], via mechanisms possibly related to the involvement of CRF 1 in the hypothalamic-pituitary-adrenal (HPA) axis [58]

TB-500's parent compound (Thymosin Beta-4) has more human clinical exposure through RegeneRx trials

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