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Science 376 , 968973 (2022)

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It should be noted that men with known conditions that would cause inflammation (such as genital tract infections, varicocele) or that used alcohol, smoked, or were currently taking antioxidants were all excluded from the study to create a more consistent base-line of existing oxidative stress (inflammation) between the groups This study also showed that the higher the measured levels of ROS, the more damage there was to sperm function

Its potential benefits stem from its role in intracellular signaling pathways that influence insulin sensitivity and ovarian function mechanisms that underlie many of the outcomes studied in clinical research.7 12 15 17 Although inositol is often associated with PCOS, much of the research points to metabolic signaling as the common thread, with reproductive and fertility-related benefits often building on those effects