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TP53 coding DNA sequence (CDS) purification from gDNA TP53 CDS was amplified as previously described [19], with the exception of the last purification step with AMPure XP (Beckman Coulter, Indianapolis, IN, USA)

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It also stimulates the release of pro-inflammatory cytokines, such as IL-6 and TNF-, and may synergize with circulating LPS to exacerbate systemic inflammation

for example, the TLR4/NF-B/IL-1 signaling pathway is activated in chronic SZ patients (197), and clozapine reduces the expression of pro-inflammatory genes such as IL-1 and IL-6 by inhibiting the TLR4/NF-B pathway (198)