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SIRT1 can also regulate the function of PGC-1 in cells by regulating the acetylation and activity level of PGC-1, as well as regulation of downstream transcription factors such as nuclear receptor peroxisome proliferator-activated receptor (PPAR), estrogen-related receptor (ERR), nuclear respiratory factor (NRFs), and mitochondrial transcription factor A (Tfam), further affecting mitochondrial production and function [17, 18], and regulating the metabolism of glucose and lipids [19]

L-glutathione is a naturally occurring antioxidant produced in the liver, composed of the amino acids L-glutamic acid, L-cysteine, and L-glycine

European Journal of Pharmacology, 570(13), 212221

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