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Moreover, their results also supported the notion that AGE production may be prevented or even diminished by antioxidant supplementation with vitamin B derivatives [305, 306], and/or vitamins A, C, and E [307]

While modulation of the GSH-antioxidant system has provided promising preclinical results, some of these compounds demonstrate unacceptable toxicity profiles (eg, buthionine sulfoximine)

Research utilizing single-cell Raman microspectroscopy has demonstrated that ME/CFS patients exhibit significant aberrations in ROS clearance pathways, including elevated oxidative stress markers and reduced antioxidant enzyme activity

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