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These findings not only provide more insight into the pathogenesis of Lyme disease but also underline how hostpathogen interactions in metabolism can play crucial roles in host defense against pathogens

Serum levels of S100 are elevated in several neurological disorders including epilepsy, traumatic brain injury and schizophrenia 45,46,47

This is in agreement with our previous study in which tamoxifen-resistant cells were reported to have high GLUL levels [22], which was attributed to the activation of the PI3K/AKT/PTEN signaling pathway, which is known to increase proliferation and cellular invasion [33]

Ghalichi F, Ghaemmaghami J, Malek A, Ostadrahimi A