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RNA sequencing analysis RNA (1 g) per sample was used for sequencing libraries generation by using KAPA mRNA HyperPrep Kit (KAPA Biosystems, Roche, Basel, Switzerland) following the manufacturers recommendations to remove ribosomal RNA

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Daver N, Cortes J, Ravandi F, Basu S, Garcia-Manero G, Jabbour E, Pemmaraju N, Hendrickson S, Pierce S, Ning J, Gonzales G, Konopleva M, Andreeff M, Borthakur G , Bueso-Ramos C, Blando J, Allison J, Kantarjian H, Sharma P