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In Gclc -KO liver, the GSH level is less than 5%, but in Chac1 -overexpression mice, the liver GSH level is approximately 15%, which is sufficient to maintain normal liver function and mitochondrial respiration (14)

However, the average costs for the cases reporting a principal diagnosis of DVT and USAT with thrombolytic(s) are higher than the average costs of all the cases in MS-DRG 252 ($36,660 versus $29,307) and the average costs for the cases reporting a principal diagnosis of DVT and USAT without thrombolytic(s) are lower than the average costs of all the cases in MS-DRG 252 ($21,538 versus $29,307)

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Such stressful conditions affect the tight coupling of ETC and ATP synthesis, leading to over reduction of electron carriers like ubiquinone (UQ) pool, thereby generating ROS (Rhoads et al., 2006