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Under stress, Nrf2 becomes unstable, translocates to the nucleus, binds to the antioxidant response element (ARE) in the promoter region, and regulates lipid peroxidation while promoting the transcription of the ferroptosis-related gene SLC7 A11 [21]

Weis research group found (142) that CP-25 had anti-inflammatory and immunomodulatory effects on AIA rats, and was able to regulate the expression of B cell activator (BAFF)/BAFF-R in CD4 + T cells to inhibit the growth of AIA-FLS co-cultured with BAFF-activated CD4 + T cells and the secretion of cytokines

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Kojic acid Kojic acid, a natural by-product of fermented rice, is a proven ingredient for treating hyperpigmentation