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Under physiological conditions, it is either remethylated to methionine or irreversibly metabolised through the transsulphuration pathway

The lack of balance between the production of ROS and the antioxidant defense system of animals will lead to DNA hydroxylation, protein denaturation, lipid peroxidation, cell apoptosis, ultimately lead to cell damage (Yang et al., 2016)

As for W303-1b/gsh1/pro1 or W303-1b/gsh1/proB, the overexpression of introduced Pro1 or ProB under the control of strong constitutive GAP promoter might allow a small amount of GSH in the host strains conferring tolerance to oxidative stress

It is an oral growth hormone secretagogue, which makes it convenient, but this comes with different considerations