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Increased FAO may be an adaptive response in patients with NAFLD attempting to reduce the lipid overload and lipotoxicity, but also produces ROS and excessive FAO may overwhelm the capacity of the anti-oxidant defense system and induce oxidative stress

(PubMed) Mattila P, Kumpulainen J

140 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 For example, a study of more than 39,000 individuals from 13 longitudinal studies of aging found associations between good social connections (e.g., frequent contact with family and friends, having a confidante or never feeling lonely) and lower risk of dementia

Typically well-tolerated with minimal discomfort