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Levine PM, De Leon CA, Galesic A, Balana A, Marotta NP, Lewis YE, et al

Finally, transcriptional artifacts induced by dying cells or stress responses may confound data interpretation, complicating the identification of genuine disease-associated molecular signatures

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UBQLN2 dysfunction compromises substrate delivery to the proteasome, resulting in the accumulation of toxic protein aggregates and progressive neurodegeneration