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Long-term metformin therapy reduces both steroidogenic and metabolic enzyme activities in the ovaries and the adrenal response to adrenocorticotrophin (ACTH), helping mitigate hyperandrogenism in women with PCOS (Lan et al., 2015

Curr Pharm Des 21:14041412 Brunst KJ, Baccarelli AA, Wright RJ (2015) Integrating mitochondriomics in childrens environmental health

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(31) found a significant negative correlation between plasma levels of HMW-HA and the apnea-hypopnea index (AHI) in patients with OSAHS, while HYAL-1 exhibited a significant positive correlation with both AHI and the oxygen desaturation index (ODI)