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Due to limited treatment options and severe adverse effects associated with MTX, multiple approaches strongly need to be investigated to counteract these severe adverse effects

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Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation

Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial