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37 Notably, RAMP1 KO mice exhibited greater fat accumulation compared to WT and RAMP3 KO mice when fed a high-fat diet (HFD)
15,16 A classic diagnostic feature is the urinary coproporphyrin isomer pattern: patients with DJS typically have normal total urine coproporphyrin levels, but markedly increased coproporphyrin I isomer levels, constituting over 80% of total urinary coproporphyrins