J Clin Psychiatry 74(4):6175 Morano S, Mandosi E, Fallarino M, Gatti A, Tiberti C, Sensi M, Gandini L, Buchetti B, Lenti L, Jannini EA (2007) Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study
Am J Psychiatry 159(4):663665 Scott F, Hampsey E, Gnanapragasam S et al (2022) Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression
[5] [6] Since glutathione, ascorbate and NADPH are present in high concentrations in plant cells it is assumed that the glutathione-ascorbate cycle plays a key role for H 2 O 2 detoxification
No large-scale, long-term human trials exist to fully understand its safety profile