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These findings are supported by enhanced DNL in overweight/obese subjects with high liver fat (18.3 3.6%, n = 13) compared to those with lower liver fat (3.1 2.7%, n = 11) while being matched for adiposity and circulating lipids [39]

Dasarathy S, Yang Y, McCullough AJ, Marczewski S, Bennett C, Kalhan SC (2011) Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis

ECs between the second and fifth passages were used for subsequent experiments

In addition to energy metabolism, ammonium accumulation affects lipid metabolism, altering membrane fluidity and receptor activation, which compromises NK cell efficiency in target cell recognition and elimination