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Blood pressure-specific Sodium (coupled with chloride) is the primary determinant of extracellular (outside of cells) fluid volume, including blood volume

3.3 Soluble uric acids organ-specific effects on metabolic dysfunction 3.3.1 Soluble uric acid-induced endothelial dysfunction and cardiovascular remodeling ( Figure 3 ) Figure 3 Persistently elevated SUA in the heart can act as a damage-associated molecular pattern under pathological conditions, recognized by Toll-like receptors (such as TLR4) on the surface of cardiomyocytes and immune cells

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Iron oxide nanoparticles augment the intercellular mitochondrial transfer-mediated therapy