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Astrocytes also exhibit dysfunctional phenotypes, including impaired potassium and glutamate buffering, which further compromise neuronal health

Intensive research efforts are required to meet the demand of identifying novel eryptosis-associated kinases and investigating their potential pharmaceutical targetability

BSO has also been used in human clinical trials for cancer, where it caused low grade toxicity 30 , suggesting it is not highly cytotoxic

Infiltration of inflammatory cells into neuronal cells leads to oligodendrocyte death-mediated demyelination, activation of neuroglial cells (including microglia and astrocytes), and axonal degeneration [161, 162]