glutathione production pathway Schematic pathways showing how can account for covariations Impaired Glutathione Synthesis in Neurodegeneration

Cysteine, a sulphur containing amino acid is one of the most important contributors to GSH production and diets lacking this amino acid may lead to GSH deficiency and excessive oxidative stress which may be the underlying contributory mechanisms in various diseases including psoriasis vulgaris [3-6]

skin tone appears uneven, and patches of skin are darker than the surrounding areas

Geier - A clinical trial of glutathione supplementation in autism spectrum disorders - Med Sci Monit - 2011

While oral supplements are convenient and accessible, they often have lower absorption rates than other forms, meaning that only a fraction reaches the liver