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No potential mutagenicity of tesamorelin acetate was revealed in a battery of tests including induction of gene mutations in bacteria (the Ames test), gene mutations in mammalian cells grown in vitro (hamster CHOK1 cells), and chromosomal damage in intact animals (bone marrow cells in mice)

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ACSL4 plays an important role in PUFA activation and determines ferroptosis sensitivity (Shin et al., 2018)