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In the subgroup with concurrent T2DM and obesity, the Mediterranean diet group exhibited slower eGFR decline compared with the low-fat diet group, suggesting renal protective effects of the Mediterranean diet in high-risk populations
GSH-driven metal reduction In catalytic or metal-complex systems, oxidation of GSH to GSSG can be coupled to transition-metal redox cycling, thereby supporting electron transfer processes involving Cu 2+ /Cu + or Fe 3+ /Fe 2+ couples 179,180
4.1.3 Indirect protection of GPX4 by regulating iron homeostasis and substrate supply Beyond directly targeting GPX4 or its related pathways, indirect strategies have also garnered attention, primarily including reducing local iron load for example, using iron chelators (Wu et al., 2023), decreasing oxidizable PUFAs substrates in membrane phospholipids through dietary intervention or locally altering lipid composition (Table 1)
