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Antibodies targeting the transferrin receptor 1 (TfR1) as direct anti-cancer agents

Both produce roughly two-thirds fat loss and one-third lean tissue loss

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Instead, it is more appropriate to envision metabolic plasticity regarding uptake of alternative metabolic substrates and promotion of metabolic rewiring as a built-in feature that has evolved to allow cancer cells to constantly adapt to changing intracellular- and extracellular metabolic conditions 2