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They accumulate in tumors without affecting normal tissue, inhibiting tumor growth and extending life (median survival time doubled) when combined with an alternating magnetic field ( In vitro assays demonstrated increased cytotoxicity against human and mouse cell lines, and a 3D spheroidal model revealed decreased TMZ efflux across the blood-brain barrier (BBB) measured by trans-endothelial electrical resistance

In the descriptive and bivariate analysis, categorical variables were presented in absolute and percentage numbers, and compared using the Chi-square test or Fishers exact test

During treatment of the PDX model of osteosarcoma, since the individuality of the mice, the tumor volume of one mouse reached 1500 mm 3 by the end of the treatment, and this mouse was not euthanized in time to obtain reliable and intuitive experimental results

Ascorbic Acid and Ascorbyl Glucosamine, the two main forms of Vitamin C, are the best of antioxidants