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In addition, quercetin suppresses invasive potential by downregulating the tight junction protein CLDN6, which paradoxically promotes motility in EMs, as well as the proliferative marker PCNA and the matrix-degrading enzymes MMP-2 and MMP-9, thereby interfering with the molecular processes required for lesion adhesion, infiltration, and expansion ( Luteolin, a bioactive flavone abundantly present in honeysuckle ( Lonicera japonica ), Sophora flavescens , S

Nature 432:466-472

Finally, Andrea Ballini and Khrystyna Zhurakivska equally contributed as co-first authors, Roberto Arrigoni and Mario Dioguardi equally contributed as co-last authors

Delayed refrigeration after delivery wastes some of the room temperature tolerance that protected the peptide during shipping