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Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice

No clinical claims or therapeutic uses are implied

In cases where surgery is not feasible or preferred by the owner due to factors like advanced age anesthesia risks cost prolonged post-op confinement extended recovery time Additionally, for dogs with multiple orthopedic issues alongside the ACL tear, such as elbow dyspepsia hip problems arthritic hocks In cases where surgical repair of only one problem may not be the most effective approach, stem cell therapy can offer pain relief for multiple injuries simultaneously

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