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Description

Sagai M, Bocci V

Mechanick JI, et al

Science 372 , eabf1230 (2021)

In a multicenter phase II study (n = 289), niraparib exhibited clinical activity in heavily pretreated mCRPC patients with DDR defects, particularly BRCA-mutated cohorts, reinforcing its therapeutic potential in biomarker-selected populations (Smith et al., 2022)