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A meta-analysis study of CKD patients (both dialytic and non-dialytic) involving 14 randomized controlled trials showed that compared to the placebo group, biotics supplementation had no statistically significant effect on the levels of circulating IS, but a substantial decrease was associated with circulating p-CS concentration

The composition also includes hyaluronic acid and macadamia nut oil , which balance the composition of the serum, taking care not to damage the hydrolipidic layer and nourish the skin