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Fedacko et al., 2007) via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, a key enzyme in the mevalonate pathway implicated in cholesterol and CoQ biosynthesis, and reduction in mitochondrial complex III activity of the electron transport chain (Schirris et al., 2015)

The study analyze shows that intracellular administration of LfcinB(2025) via fusogenic liposomes results in powerful cytotoxic activity involving the action of caspases and cathepsin B without requiring ROS generation [45].The mechanism underlying this peptide emphasizes that it could be used as a novel drug delivery system, maximizing its efficacy [46]

Kim H, et al

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