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Benefit 8: Enhanced Energy Production Fatigue is a major symptom for patients with chronic illnesses such as Lyme disease or ME/CFS

As we demonstrated here, cortistatin modulates the production of these factors by DRGs, central terminals, and the sciatic nerve, and it restores the endogenous production of some of them (GDNF) while reducing others (BDNF) in an adequate balance at the lesion site (neurotrophic versus neuropathic actions), which could be determinant in the regenerative and neuroprotective effect of the neuropeptide in the repairing nerve

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