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Ferroptosis in lung cancer: from molecular mechanisms to prognostic and therapeutic opportunities

Staying hydrated is also important

On the other hand, because of the high concentration of GSH in many tumors and its high reactivity, GSH is used as an activator of prodrugs, such as romidepsin, which is used to treat cutaneous T-cell lymphoma and other peripheral T-cell lymphomas [197]

Ferric iron (Fe 3+ ) is stored within ferritin in the cytoplasm, whereas Fe 2+ for ferroptosis induction is either imported via CD44 from the extracellular compartment [22] or provided via lysosomal ferritin degradation and subsequent reduction [23]