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In a study conducted by Ng et

These phospholipids readily undergo Fe + -dependent lipid peroxidation, creating a pro-ferroptotic microenvironment ( 4-Hydroxynonenal (4-HNE), a characteristic end-product of -6 polyunsaturated fatty acid (e.g., arachidonic acid) lipid peroxidation, serves as a key molecular biomarker of ferroptosis ( Cumulatively, the core mechanism of ferroptosis involves synergistic amplification of lipid peroxidation cascades through multiple feedback loops

High-dose MPs (10 mg/L) additionally decrease liver weights in male progeny, concomitant with hepatic oxidative stress, inflammatory cell infiltration, upregulated proinflammatory cytokines, glucose metabolism dysregulation, and lipid deposition (102, 103)