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Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2006 [accessed 2012 May 10]

A direct association between elevated levels of CRP, as well as other markers of inflammation, and cigarette smoking has been reported in several investigations 1,10,11,12,13,14,15,16,17,18,19,20,21 , most studies showing a dose-response relationship between CRP levels and smoking intensity and/or duration 14,17,18,21,22

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SBS2 and SBS13 mutational signatures, which are associated with the AID/APOBEC activity of cytidine deaminases and innate immune response, are frequently detected in LCNS cohorts and as well as in a variety of other cancer cohorts including within smoking lung cancer [39, 52, 53]