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Keywords: alcohol use, tobacco use, Canada, mortality metrics, guidance on alcohol and health Introduction Alcohol use is a causal risk factor for over 230 disease conditions based on the three-digit International Classification of Diseases, Revision 10 (ICD-10) codes (1)

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To reduce the influence on our model of multiple observations coming from the same study, we adjusted the standard errors of effect sizes reported for multiple non-mutually exclusive exposure groups in each study by a factor matching the number of repeated measurements within each agesexsmoking status group (Supplementary Information Section 2.2)