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Chronic Oxidative Stress (Depletes Glutathione Faster Than Its Made) Anything that increases free radical production depletes glutathione: Chronic inflammation (autoimmune diseases, obesity, metabolic syndrome) Environmental toxins (air pollution, pesticides, heavy metals) Alcohol consumption (glutathione is rapidly depleted in liver detoxification) Poor diet (high in processed foods, seed oils, sugar) Intense exercise (without adequate recovery) When oxidative stress exceeds your bodys capacity to recycle GSSG back to GSH, levels drop [4]

Under normal conditions, cells maintain a high GSH: GSSG ratio, which can decrease under oxidative stress

(7) Vladimir N Anisimov, Vladimir K H Khavinson, Mauro Provinciali, Irina N Alimova, et al (2002) Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice International Journal of Cancer, 2002 Sep 1, Volume 101 (Issue 1), Pages 7-10