Since VIP is ineffective at stimulating gland secretion in CF, then it seems an unlikely candidate to mediate the increased muc5B concentrations (which is largely expressed in the glands and to a lesser extent in surface goblet cells [134]) that are observed during CF exacerbations [135]
Four treatments were included in this experiment: (1) normal temperature (NT): plants shoots grew in the normal glasshouse temperature, no heating for roots zone (about 22 C with a range of 2025 C)
While outcomes are improved, clinical translation of strategies involving the transplantation of allogeneic and/or manipulated cells has been hampered due to safety concerns and the extended FDA regulatory approvals required
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