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So Selye began to suggest that subjecting an animal to prolonged stress led to tissue changes and physiological changes with the release of certain hormones, that would then cause disease and ultimately the death of the animal." And so the idea of stress and its potential costs to the body was born

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Aux tats-Unis, les Centres pour le contrle et la prvention des maladies dcrivent l'usage de tabac comme la premire cause de mortalit vitable et estiment que le tabac tue prs de 6 millions de personnes chaque anne dans le monde [5]