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The BCL-2 family of proteins are divided into three subgroups: (1) the pro-apoptotic BH3-only proteins, such as Bcl-2 Interacting Mediator of cell death (BIM), the p53 upregulated modulator of apoptosis (PUMA) and phorbol-12-myristate-13-acetate-induced protein 1 (NOXA), which are initiators of apoptosis