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I really want to love this, given that it has tobacco and seems to be leather-heavy

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Works in CNS and PNS Mechanisms of Action Direct Agonism of Nicotinic cholinergic receptors Ionotropic type receptors When binds it opens a Na+ channel and depolarizes the cell membrane May produce a secondary Functional antagonism Initial agonism may be followed by desensitization of the nicotinic ACH receptor Nicotine affects nicotinic Acetylcholine receptors at the autonomic ganglia and the NMJ to produce peripheral effects Peripheral Effects A sympathomimetic- Adrenal glands release epinephrine and norepinephrine Increases heart rate, blood pressure, respiration A parasympathomimetic Increases smooth muscle (GI tract) activity Increases HCL production in stomach/nausea Chronic diarrhea, Colitis Body weight- appetite suppression, increased metabolic rates Nicotine Pharmacology- High concentrations of nicotine binding in: cerebral cortex Thalamus locus coeruleus Hippocampus Cerebellum Striatum substantianigra Enhanced sensory and cognitive processes Disequilibrium, motor incoordination, dizziness Effects on Motor Performance High concentrations of nicotine binding in: Raphe Nucleus VTA Mood/reward Central Effects Arousal Improves vigilance & rapid information processing Improves mental performance & memory Improved motor steadiness Stress Reduction Reward

Enforcement Action to Protect Revenue and Public Safety The importation of tobacco products is highly regulated from both tax and consumer safety perspectives, said Cheryl M