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Figure 8 Discussion It is well known that mitophagy, the principal mechanism to eliminate impaired mitochondria, is important for the regulation of mitochondrial function and cellular homeostasis ( in vivo and in vitro , suggesting that HS treatment stabilized PINK1 at the outer mitochondrial membrane and thereby recruits more Parkin to damage mitochondria

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Typically, this condition is found in Cuban cigars and is commonly known as a sick period