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doi: 10.3389/fonc.2025.1612605 Received 30 April 2025 Accepted 03 September 2025 Published 24 September 2025 Volume 15 - 2025 Edited by Giulia Maria Stella, University of Pavia, Italy Reviewed by Larisa Litovchick, Virginia Commonwealth University, United States Shufeng Sun, National Institutes of Health (NIH), United States Updates Copyright 2025 Zhou, Lu, Hu, Suzuki and Zhou