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However, spontaneous germ cell necrosis takes place very sporadically in the testes of wild type or Tp53-/- mutant mice at 6-8 weeks of age (52)

Instead, the tobacco industry made a preemptive strike by funneling a total of $18 million over 14 years to the American Medical Associationthe only major health organization to withhold its endorsement of the reportin a research program to identify and remove any possible harmful components of cigarette smoke

For cigarette smoke, that threshold is roughly 12 lbs minimum for light exposure

Testosterone synthesis inhibition: Smoking has been shown to inhibit the production of testosterone in the testes