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Robin Wright, Journalist : There were those in the administration who did not believe in international institutions to begin with, so there was skepticism about whether it was even worth trying it, but Powell made the case you have to go to the UN to be seen to have at least tried and if they succeeded, then the world would come back and say, oh, you were right. Narrator: Reluctantly, Bush accepted Blair and Powells advice, and ordered Powell himself to make the case to the UN

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However, of note, recent studies have revealed that APR-246 does not actually kill malignant cells by targeting mutant p53 since CRISPR mediated removal of mutant p53 had no impact on sensitivity to this agent in a broad range of cancer cell lines [218]