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To combat this public health concern, the FDA announced in a March 15 statement that it was issuing an advance notice of proposed rulemaking (ANPRM) to explore reducing nicotine in cigarettes to "minimally or nonaddictive levels." The FDA first announced a comprehensive regulatory plan that included lowering nicotine levels in cigarettes in July 2017

Evolving knowledge about e-cigarettes merited the policy change, KU human resources director Ola Faucher said

Tobacco contains nicotine, cadmium, and lead, which are mutagenic and carcinogenic and cause damage to cells undergoing rapid multiplication, including germ cells in the testis 26

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