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Nicotine also has been documented to have an effect on serotonin receptors (5HT1 and 5HT2), which subsequently affects the bodys response to serotonin, supporting the link between exposure to nicotine in adolescence and risk of mood disorders later in life 47,48

Areas to avoid include the neck, face, underarms, mucosal regions, and freshly shaved skin because these zones are more sensitive and prone to irritation, pigmentation, or allergic reactions