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In patients with alcohol use disorder, the differential diagnosis includes nutritional and hereditary optic neuropathies, as well as so-called tobacco-alcohol optic neuropathy, especially because the final common pathway of optic nerve compromise is likely via mitochondrial dysfunction (20)

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As the pattern of missingness was assumed to be Missing at Random (MAR), we conducted a complete records analysis, retaining only individuals with full data on the relevant outcome and exposure variables Role models, substance use, and passive exposure A large proportion of adolescents (83.2%) reported regular exposure to at least one smoker in their immediate environment