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Additionally, MAVS has been shown to connect the innate immune Nod1/RIP2 signaling pathway, inflammation, and mitochondrial homeostasis by regulating mitophagy, playing a crucial role in cardiac remodeling ( In summary, mitophagy influences the progression of fibrosis by clearing damaged mitochondria and their pro-inflammatory substances, reducing the activation of inflammasomes, pro-inflammatory factors, and signaling molecules, and inhibiting the innate immune responses